/* ============================================
   gentests.de - Gen-Enzyklopädie Design System
   ============================================ */

/* Google Fonts */
@import url('https://fonts.googleapis.com/css2?family=Inter:wght@300;400;500;600;700;800&family=Source+Serif+4:wght@400;600;700&display=swap');

/* ============================================
   CSS Variables / Design Tokens
   ============================================ */
:root {
  /* Colors - Wissenschaftliche Palette */
  --color-primary: #2563eb;
  --color-primary-light: #3b82f6;
  --color-primary-dark: #1e40af;
  --color-secondary: #10b981;
  --color-secondary-light: #34d399;
  --color-secondary-dark: #059669;
  --color-accent: #8b5cf6;
  --color-accent-light: #a78bfa;

  /* DNA-inspirierte Farben */
  --color-dna-blue: #4f46e5;
  --color-dna-green: #14b8a6;
  --color-dna-purple: #7c3aed;
  --color-dna-pink: #ec4899;

  /* Neutrals */
  --color-bg: #ffffff;
  --color-surface: #f8fafc;
  --color-surface-hover: #f1f5f9;
  --color-border: #e2e8f0;
  --color-text: #1e293b;
  --color-text-light: #64748b;
  --color-text-muted: #94a3b8;

  /* Gradients */
  --gradient-hero: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
  --gradient-card: linear-gradient(135deg, #667eea15 0%, #764ba215 100%);
  --gradient-accent: linear-gradient(135deg, #f093fb 0%, #f5576c 100%);
  --gradient-science: linear-gradient(135deg, #4facfe 0%, #00f2fe 100%);

  /* Typography */
  --font-sans: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', sans-serif;
  --font-serif: 'Source Serif 4', Georgia, serif;

  /* Spacing */
  --space-xs: 0.25rem;
  --space-sm: 0.5rem;
  --space-md: 1rem;
  --space-lg: 1.5rem;
  --space-xl: 2rem;
  --space-2xl: 3rem;
  --space-3xl: 4rem;

  /* Border Radius */
  --radius-sm: 0.375rem;
  --radius-md: 0.5rem;
  --radius-lg: 0.75rem;
  --radius-xl: 1rem;
  --radius-2xl: 1.5rem;

  /* Shadows */
  --shadow-sm: 0 1px 2px 0 rgb(0 0 0 / 0.05);
  --shadow-md: 0 4px 6px -1px rgb(0 0 0 / 0.1), 0 2px 4px -2px rgb(0 0 0 / 0.1);
  --shadow-lg: 0 10px 15px -3px rgb(0 0 0 / 0.1), 0 4px 6px -4px rgb(0 0 0 / 0.1);
  --shadow-xl: 0 20px 25px -5px rgb(0 0 0 / 0.1), 0 8px 10px -6px rgb(0 0 0 / 0.1);
  --shadow-glow: 0 0 20px rgba(102, 126, 234, 0.4);

  /* Transitions */
  --transition-fast: 150ms ease;
  --transition-base: 250ms ease;
  --transition-slow: 350ms ease;
}

/* ============================================
   Reset & Base Styles
   ============================================ */
* {
  margin: 0;
  padding: 0;
  box-sizing: border-box;
}

html {
  font-size: 16px;
  scroll-behavior: smooth;
}

body {
  font-family: var(--font-sans);
  color: var(--color-text);
  background-color: var(--color-bg);
  line-height: 1.6;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

/* ============================================
   Typography
   ============================================ */
body h1,
body h2,
body h3,
body h4,
body h5,
body h6 {
  font-weight: 700;
  line-height: 1.2;
  margin-bottom: var(--space-md);
  color: var(--color-text);
}

body h1 {
  font-size: 3rem;
  font-weight: 800;
  letter-spacing: -0.02em;
}

body h2 {
  font-size: 2.25rem;
  letter-spacing: -0.01em;
}

body h3 {
  font-size: 1.5rem;
  font-weight: 600;
  color: var(--color-text-light);
}

body h4 {
  font-size: 1.5rem;
}

body h5 {
  font-size: 1.25rem;
}

body h6 {
  font-size: 1rem;
}

p {
  margin-bottom: var(--space-md);
  color: var(--color-text-light);
}

a {
  color: var(--color-primary);
  text-decoration: none;
  transition: color var(--transition-fast);
}

a:hover {
  color: var(--color-primary-dark);
}

/* ============================================
   Layout
   ============================================ */
.container {
  width: 100%;
  max-width: 1200px;
  margin: 0 auto;
  padding: 0 var(--space-lg);
}

.container-wide {
  max-width: 1400px;
}

.container-narrow {
  max-width: 800px;
}

/* ============================================
   Header & Navigation
   ============================================ */
.header {
  background: rgba(255, 255, 255, 0.95);
  backdrop-filter: blur(10px);
  border-bottom: 1px solid var(--color-border);
  position: sticky;
  top: 0;
  z-index: 1000;
  box-shadow: var(--shadow-sm);
}

.nav {
  display: flex;
  justify-content: space-between;
  align-items: center;
  padding: var(--space-lg) 0;
}

.logo {
  font-size: 1.5rem;
  font-weight: 800;
  background: var(--gradient-hero);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
}

.nav-links {
  display: flex;
  gap: var(--space-xl);
  list-style: none;
}

.nav-links a {
  font-weight: 500;
  color: var(--color-text);
  transition: color var(--transition-fast);
}

.nav-links a:hover {
  color: var(--color-primary);
}

/* ============================================
   Hero Section
   ============================================ */
.hero {
  background: var(--gradient-hero);
  color: white;
  padding: var(--space-3xl) 0;
  text-align: center;
  position: relative;
  overflow: hidden;
}

.hero::before {
  content: '';
  position: absolute;
  top: 0;
  left: 0;
  right: 0;
  bottom: 0;
  background: url('data:image/svg+xml,<svg width="60" height="60" xmlns="http://www.w3.org/2000/svg"><path d="M30 0L30 60M0 30L60 30" stroke="rgba(255,255,255,0.1)" stroke-width="1"/></svg>');
  opacity: 0.3;
}

.hero-content {
  position: relative;
}

.hero h1 {
  color: white;
  font-size: 3.5rem;
  margin-bottom: var(--space-lg);
  text-shadow: 0 2px 10px rgba(0, 0, 0, 0.2);
}

.hero p {
  font-size: 1.25rem;
  color: rgba(255, 255, 255, 0.95);
  margin-bottom: var(--space-2xl);
  max-width: 600px;
  margin-left: auto;
  margin-right: auto;
}

/* ============================================
   Search Component
   ============================================ */
.search-wrapper {
  max-width: 600px;
  margin: 0 auto;
  position: relative;
  z-index: 100;
}

.search-input {
  width: 100%;
  padding: var(--space-lg) var(--space-xl);
  padding-left: 3.5rem;
  font-size: 1.125rem;
  border: none;
  border-radius: var(--radius-xl);
  box-shadow: var(--shadow-xl);
  background: white;
  transition: all var(--transition-base);
}

.search-input:focus {
  outline: none;
  box-shadow: var(--shadow-xl), 0 0 0 3px rgba(37, 99, 235, 0.1);
  transform: translateY(-2px);
}

.search-icon {
  position: absolute;
  left: var(--space-lg);
  top: 50%;
  transform: translateY(-50%);
  color: var(--color-text-muted);
  font-size: 1.5rem;
}

.search-results {
  position: absolute;
  top: calc(100% + var(--space-sm));
  left: 0;
  right: 0;
  background: white;
  border-radius: var(--radius-lg);
  box-shadow: var(--shadow-xl);
  max-height: 400px;
  overflow-y: auto;
  display: none;
  z-index: 10000;
}

.search-results.active {
  display: block;
}

.search-result-item {
  padding: var(--space-md) var(--space-lg);
  border-bottom: 1px solid var(--color-border);
  cursor: pointer;
  transition: background-color var(--transition-fast);
}

.search-result-item:hover,
.search-result-item.selected {
  background-color: var(--color-surface);
}

.search-result-item:last-child {
  border-bottom: none;
}

.search-result-symbol {
  font-weight: 700;
  color: var(--color-primary);
  font-size: 1.125rem;
}

.search-result-name {
  color: var(--color-text-light);
  font-size: 0.875rem;
}

.search-result-snp {
  font-size: 0.75rem;
  color: var(--color-primary);
  font-weight: 600;
  margin-top: 0.25rem;
  font-family: 'Courier New', monospace;
}

.search-result-alias {
  font-size: 0.75rem;
  color: var(--color-accent);
  font-weight: 600;
  margin-top: 0.25rem;
  font-style: italic;
}

/* ============================================
   Cards
   ============================================ */
.card {
  background: white;
  border-radius: var(--radius-lg);
  padding: var(--space-xl);
  box-shadow: var(--shadow-md);
  transition: all var(--transition-base);
  border: 1px solid var(--color-border);
}

.card:hover {
  box-shadow: var(--shadow-lg);
  transform: translateY(-4px);
}

.card-gradient {
  background: var(--gradient-card);
  border: none;
}

.card-header {
  margin-bottom: var(--space-lg);
}

.card-title {
  font-size: 1.5rem;
  margin-bottom: var(--space-sm);
}

.card-subtitle {
  color: var(--color-text-light);
  font-size: 0.875rem;
}

/* ============================================
   Gene Card (Special)
   ============================================ */
.gene-card {
  display: block;
  color: inherit;
  text-decoration: none;
}

.gene-symbol {
  display: inline-block;
  padding: var(--space-sm) var(--space-md);
  background: var(--gradient-hero);
  color: white;
  border-radius: var(--radius-md);
  font-weight: 700;
  font-size: 1.25rem;
  margin-bottom: var(--space-md);
}

.gene-name {
  font-size: 1.125rem;
  font-weight: 600;
  color: var(--color-text);
  margin-bottom: var(--space-sm);
}

.gene-description {
  color: var(--color-text-light);
  font-size: 0.9375rem;
  line-height: 1.6;
}

.gene-meta {
  display: flex;
  gap: var(--space-lg);
  margin-top: var(--space-md);
  padding-top: var(--space-md);
  border-top: 1px solid var(--color-border);
  font-size: 0.875rem;
  color: var(--color-text-muted);
}

/* ============================================
   Grid Layouts
   ============================================ */
.grid {
  display: grid;
  gap: var(--space-xl);
}

.grid-2 {
  grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
}

.grid-3 {
  grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
}

.grid-4 {
  grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
}

/* ============================================
   Buttons
   ============================================ */
.btn {
  display: inline-block;
  padding: var(--space-md) var(--space-xl);
  font-weight: 600;
  border-radius: var(--radius-md);
  transition: all var(--transition-base);
  cursor: pointer;
  border: none;
  font-size: 1rem;
  text-align: center;
}

.btn-primary {
  background: var(--gradient-hero);
  color: white;
  box-shadow: var(--shadow-md);
}

.btn-primary:hover {
  box-shadow: var(--shadow-lg);
  transform: translateY(-2px);
}

.btn-secondary {
  background: white;
  color: var(--color-primary);
  border: 2px solid var(--color-primary);
}

.btn-secondary:hover {
  background: var(--color-primary);
  color: white;
}

/* ============================================
   Badges & Tags
   ============================================ */
.badge {
  display: inline-block;
  padding: var(--space-xs) var(--space-md);
  border-radius: var(--radius-sm);
  font-size: 0.875rem;
  font-weight: 600;
}

.badge-primary {
  background: var(--color-primary-light);
  color: white;
}

.badge-secondary {
  background: var(--color-secondary-light);
  color: white;
}

.badge-accent {
  background: var(--color-accent-light);
  color: white;
}

/* ============================================
   Info Boxes
   ============================================ */
.info-box {
  padding: var(--space-lg);
  border-radius: var(--radius-lg);
  border-left: 4px solid;
  margin-bottom: var(--space-lg);
}

.info-box-info {
  background: rgba(37, 99, 235, 0.1);
  border-color: var(--color-primary);
}

.info-box-warning {
  background: rgba(245, 158, 11, 0.1);
  border-color: #f59e0b;
}

.info-box-success {
  background: rgba(16, 185, 129, 0.1);
  border-color: var(--color-secondary);
}

/* ============================================
   Section Spacing
   ============================================ */
.section {
  padding: var(--space-3xl) 0;
}

.section-sm {
  padding: var(--space-2xl) 0;
}

.section-lg {
  padding: 5rem 0;
}

/* ============================================
   Footer
   ============================================ */
.footer {
  background: var(--color-surface);
  border-top: 1px solid var(--color-border);
  padding: var(--space-2xl) 0;
  margin-top: var(--space-3xl);
}

.footer-content {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
  gap: var(--space-xl);
}

.footer-section h4 {
  margin-bottom: var(--space-md);
  color: var(--color-text);
}

.footer-links {
  list-style: none;
}

.footer-links li {
  margin-bottom: var(--space-sm);
}

.footer-links a {
  color: var(--color-text-light);
  transition: color var(--transition-fast);
}

.footer-links a:hover {
  color: var(--color-primary);
}

.footer-bottom {
  margin-top: var(--space-xl);
  padding-top: var(--space-lg);
  border-top: 1px solid var(--color-border);
  text-align: center;
  color: var(--color-text-muted);
  font-size: 0.875rem;
}

/* ============================================
   Responsive Design
   ============================================ */
@media (max-width: 768px) {
  html {
    font-size: 14px;
  }

  h1 {
    font-size: 2.5rem;
  }

  .hero h1 {
    font-size: 2.5rem;
  }

  .nav {
    flex-direction: column;
    gap: var(--space-md);
  }

  .nav-links {
    gap: var(--space-md);
  }

  .grid-2,
  .grid-3,
  .grid-4 {
    grid-template-columns: 1fr;
  }
}

/* ============================================
   Utility Classes
   ============================================ */
.text-center {
  text-align: center;
}

.text-muted {
  color: var(--color-text-muted);
}

.mt-sm {
  margin-top: var(--space-sm);
}

.mt-md {
  margin-top: var(--space-md);
}

.mt-lg {
  margin-top: var(--space-lg);
}

.mt-xl {
  margin-top: var(--space-xl);
}

.mb-sm {
  margin-bottom: var(--space-sm);
}

.mb-md {
  margin-bottom: var(--space-md);
}

.mb-lg {
  margin-bottom: var(--space-lg);
}

.mb-xl {
  margin-bottom: var(--space-xl);
}

/* ============================================
   SNP Components
   ============================================ */
.snp-section {
  margin-top: var(--space-2xl);
}

.snp-card {
  background: var(--color-surface);
  border-radius: var(--radius-lg);
  padding: var(--space-lg);
  margin-bottom: var(--space-md);
  border-left: 4px solid var(--color-primary);
  transition: all var(--transition-base);
}

.snp-card:hover {
  background: var(--color-surface-hover);
  transform: translateX(4px);
}

.snp-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  margin-bottom: var(--space-md);
  flex-wrap: wrap;
  gap: var(--space-md);
}

.snp-id {
  font-size: 1.125rem;
  font-weight: 700;
  color: var(--color-primary);
  font-family: 'Courier New', monospace;
}

.snp-position {
  font-size: 0.875rem;
  color: var(--color-text-muted);
  font-family: 'Courier New', monospace;
}

.allele-display {
  display: flex;
  gap: var(--space-md);
  align-items: center;
  margin: var(--space-md) 0;
}

.allele-box {
  display: inline-flex;
  flex-direction: column;
  align-items: center;
  gap: var(--space-xs);
}

.allele-label {
  font-size: 0.75rem;
  color: var(--color-text-muted);
  text-transform: uppercase;
  font-weight: 600;
}

.search-result-item.selected {
  font-weight: 600;
}

.allele-value {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 3rem;
  height: 3rem;
  background: white;
  border: 2px solid var(--color-primary);
  border-radius: var(--radius-md);
  font-size: 1.25rem;
  font-weight: 700;
  color: var(--color-primary);
  font-family: 'Courier New', monospace;
}

.allele-box.allele-reference .allele-value {
  background: var(--color-primary);
  color: white;
}

.allele-box.allele-alternative .allele-value {
  background: white;
  border-color: var(--color-secondary);
  color: var(--color-secondary);
}

.allele-box.allele-normal .allele-value {
  background: white;
  border-color: var(--color-secondary);
  color: var(--color-secondary);
}

.allele-box.allele-risk .allele-value {
  background: white;
  border-color: #ef4444;
  /* red-500 */
  color: #ef4444;
}

.allele-separator {
  font-size: 1.5rem;
  color: var(--color-text-muted);
  font-weight: 300;
}

.snp-description {
  color: var(--color-text-light);
  line-height: 1.6;
  margin-top: var(--space-sm);
}

.snp-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
  gap: var(--space-lg);
  margin-top: var(--space-lg);
}

/* Category-specific colors */
.category-badge {
  display: inline-block;
  padding: var(--space-xs) var(--space-md);
  border-radius: var(--radius-sm);
  font-size: 0.875rem;
  font-weight: 600;
}

.category-stoffwechsel {
  background: linear-gradient(135deg, #10b981 0%, #059669 100%);
  color: white;
}

.category-vitamine {
  background: linear-gradient(135deg, #f59e0b 0%, #d97706 100%);
  color: white;
}

.category-entgiftung {
  background: linear-gradient(135deg, #8b5cf6 0%, #7c3aed 100%);
  color: white;
}

.category-fitness {
  background: linear-gradient(135deg, #ef4444 0%, #dc2626 100%);
  color: white;
}

.category-immunsystem {
  background: linear-gradient(135deg, #3b82f6 0%, #2563eb 100%);
  color: white;
}